Renovascular hypertension pathology

Renovascular hypertension is due to ischemia caused renin - angiotensin - aldosterone axis and the activation. Suffering from renal perfusion due to a decrease in the release of renin, the renin-angiotensin reasons prompted into angiotensin Ⅰ, angiotensin Ⅰ as angiotensin-converting-enzyme conversion of angiotensin Ⅱ. Angiotensin Ⅱ is a strong contraction of blood vessels, angiotensin Ⅱ (A Ⅱ) can stimulate the adrenal gland secretion of aldosterone, a sodium retention. Obstructive renal artery disease can be unilateral or bilateral disease, or occurred in patients with kidney alone, the different types of vascular renal pathophysiology of hypertension is not the same. In renal mode (renal, a clamp-type kidney), ischemic renal Shuinazhuliu lead to the release of renin, but the opposite appears normal kidney diuretic row of pressure sodium, so that patients actually a negative balance of sodium, Further increased the renin release. Kidney in a single mode (single kidney, kidney clamp-type), not the impact of contralateral kidney, thus preventing the loss of sodium, extracellular fluid volume increase in blood renin inhibition activity, increased blood pressure in patients with such major Is caused by excess body fluids. In patients with renal artery stenosis with a similar situation.