1. Accordance with the original choice of effective cancer drugs. If spinal metastatic breast cancer-testis available; prostate cancer metastasis women's sex hormones can be used; available thyroxine treatment of thyroid cancer. 2. Advanced metastatic bone cancer is a malignant tumor to prolong life and alleviate suffering patients, according to the original choice of effective cancer chemotherapy drugs, blood transfusion, added to reinstate albumin and TCM treatment is necessary. 3. Appropriate application of pain medicine, as appropriate application of strong pain medicine is reasonable.