Disease also known as Lima beans yellow beans is due to eating beans and broad beans or smell the smell of pollen and bean induced acute anemia, jaundice and hemoglobinuria as the main clinical manifestations of the disease. More than 90% occurring in men, and most found in children under age 5. In the southwest, south, east and north China have been found all over, in the Guangdong, Sichuan, Guangxi, Hunan, Jiangxi to the most.
Erythrocyte glucose -6-- phosphate dehydrogenase (G6PD) has a genetic defect in the consumption of fresh green beans or bean pollen exposure occurs after both acute hemolytic anemia - bean disease. Pathogenic mechanisms are not yet very clear, but the genetic defects known to have sensitive red blood cells, a factor in the case of beans, caused by acute intravascular hemolysis.
[Clinical manifestations]
Early aversion to cold, fever, dizziness, fatigue, weakness, anorexia, abdominal pain, followed by jaundice, anemia, hemoglobin in urine, urine color was soy sauce, then fever, fatigue fatigue increased, sustainable 3 days or so. And hemolytic anemia occur at the same time, vomiting, diarrhea and abdominal pain increased, hepatomegaly, abnormal liver function, approximately 50% of patients with splenomegaly. Seen severe cases coma, convulsions and acute renal failure, if the aid is often less than 1 to 2 days at death.
[Diagnostic Methods]
1. Are eating beans green beans or inhalation of pollen history.
2. Clinical features:
① incubation period of several hours to 48 hours.
② performance poisoning: early aversion to cold, fever, dizziness, fatigue, weakness, anorexia, abdominal pain, followed by jaundice, anemia, hemoglobin in urine, urine color was soy sauce, then fever, fatigue fatigue increased, sustainable 3 around June.
③ The check: methemoglobin reduction test (MHb) to restore normal rates of> 75% (colorimetric method), broad bean MHb reduction rate in patients with 31% to 74% (genetic heterozygotes), with reduction rate "30% (pure zygosity); blood corpuscles with denatured globin (He Enzi bodies) can be more than 5% (normal is 0 to 0.28%).
)
Erythrocyte glucose -6-- phosphate dehydrogenase (G6PD) has a genetic defect in the consumption of fresh green beans or bean pollen exposure occurs after both acute hemolytic anemia - bean disease. Pathogenic mechanisms are not yet very clear, but the genetic defects known to have sensitive red blood cells, a factor in the case of beans, caused by acute intravascular hemolysis.
[Clinical manifestations]
Early aversion to cold, fever, dizziness, fatigue, weakness, anorexia, abdominal pain, followed by jaundice, anemia, hemoglobin in urine, urine color was soy sauce, then fever, fatigue fatigue increased, sustainable 3 days or so. And hemolytic anemia occur at the same time, vomiting, diarrhea and abdominal pain increased, hepatomegaly, abnormal liver function, approximately 50% of patients with splenomegaly. Seen severe cases coma, convulsions and acute renal failure, if the aid is often less than 1 to 2 days at death.
[Diagnostic Methods]
1. Are eating beans green beans or inhalation of pollen history.
2. Clinical features:
① incubation period of several hours to 48 hours.
② performance poisoning: early aversion to cold, fever, dizziness, fatigue, weakness, anorexia, abdominal pain, followed by jaundice, anemia, hemoglobin in urine, urine color was soy sauce, then fever, fatigue fatigue increased, sustainable 3 around June.
③ The check: methemoglobin reduction test (MHb) to restore normal rates of> 75% (colorimetric method), broad bean MHb reduction rate in patients with 31% to 74% (genetic heterozygotes), with reduction rate "30% (pure zygosity); blood corpuscles with denatured globin (He Enzi bodies) can be more than 5% (normal is 0 to 0.28%).
)
