Archive for January 2012

Statin Effects in Women Versus Men

Tuesday, January 31, 2012

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Complete report

Objectives: The aim of this study was to evaluate the effect of statins in decreasing cardiovascular events in women and men.

Background: Published data reviews have suggested that statins might not be as effective in women as in men in decreasing cardiovascular events.

Methods: Published data searches and contacts with investigators identified 18 randomized clinical trials of statins with sex-specific outcomes (N = 141,235, 40,275 women, 21,468 cardiovascular events). Odds ratios (ORs) and 95% confidence intervals (CIs) for cardiovascular events were calculated for women and men separately with random effects meta-analyses.

Results: The cardiovascular event rate was lower among those randomized to statin intervention than in those randomized to control (low-dose statin in 4 studies, placebo in 11 studies, usual care in 3 studies). The benefit of statins was statistically significant in both sexes, regardless of the type of control, baseline risk, or type of endpoint and in both primary and secondary prevention. All-cause mortality was also lower with statin therapy both in women and men without significant interaction by sex.

Conclusions: Statin therapy is associated with significant decreases in cardiovascular events and in all-cause mortality in women and men. Statin therapy should be used in appropriate patients without regard to sex.
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Chocolate Consumption Reduces Risk of Stroke in Women

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Complete report

Ample evidence indicates that chocolate may have beneficial effects on the cardiovascular system. Chocolate consumption has been shown to reduce systolic and diastolic blood pressure in short-term randomized feeding trials (1), and has been demonstrated to improve endothelial and platelet function and to ameliorate insulin resistance (2). Moreover, flavonoids in chocolate possess strong antioxidant activity and can suppress oxidation of low-density lipoprotein cholesterol (3).

In the autumn of 1997, 39,227 women completed a questionnaire that included approximately 350 items concerning diet and other lifestyle factors (4). We excluded women with a missing national identification number, those with implausible values for total energy intake, and those with a history of cancer, stroke, coronary heart disease, or diabetes mellitus before baseline. That left 33,372 women, age 49 to 83 years, for analysis. The study was approved by the Ethical Review Board at the Karolinska Institutet (Stockholm, Sweden). Chocolate consumption was assessed using a self-administered food-frequency questionnaire. Women were asked to indicate how often on average they had consumed chocolate and 95 other foods during the previous year. There were 8 pre-defined consumption categories ranging from never to ≥3 times a day. In the 1990s, approximately 90% of chocolate consumption in Sweden was milk chocolate, containing approximately 30% cocoa solids (5).

Our findings are broadly consistent with those from previous smaller studies, which observed either a statistically significant (136 stroke cases) (6) or a nonsignificant (111 or 469 stroke cases) (5,7) inverse association between chocolate consumption and total stroke. In the present study, only women in the highest quartile of chocolate consumption (median 66.5 g/week) had a significantly reduced risk of stroke, suggesting that higher intakes are necessary for a potential protective effect. The reason for the stronger association observed for hemorrhagic stroke than for cerebral infarction is unclear.

In summary, results from this cohort of women suggest that a high chocolate consumption is associated with a lower risk of stroke.
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Are diet soft drinks bad for you?

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New study finds potential link between daily consumption of diet soft drinks and risk of vascular events

Individuals who drink diet soft drinks on a daily basis may be at increased risk of suffering vascular events such as stroke, heart attack, and vascular death. This is according to a new study by Hannah Gardener and her colleagues from the University of Miami Miller School of Medicine and at Columbia University Medical Center. However, in contrast, they found that regular soft drink consumption and a more moderate intake of diet soft drinks do not appear to be linked to a higher risk of vascular events. The research¹ appears online in the Journal of General Internal Medicine², published by Springer.

In the current climate of escalating obesity rates, artificially sweetened soft drinks are marketed as healthier alternatives to sugar-sweetened beverages, due to their lack of calories. However, the long-term health consequences of drinking diet soft drinks remain unclear.

Gardener and team examined the relationship between both diet and regular soft drink consumption and risk of stroke, myocardial infarction (or heart attack), and vascular death. Data were analyzed from 2,564 participants in the NIH-funded Northern Manhattan Study, which was designed to determine stroke incidence, risk factors and prognosis in a multi-ethnic urban population. The researchers looked at how often individuals drank soft drinks - diet and regular - and the number of vascular events that occurred over a ten-year period.

They found that those who drank diet soft drinks daily were 43 percent more likely to have suffered a vascular event than those who drank none, after taking into account pre-existing vascular conditions such as metabolic syndrome, diabetes and high blood pressure. Light diet soft drink users, i.e. those who drank between one a month and six a week, and those who chose regular soft drinks were not more likely to suffer vascular events.

Gardener concludes: "Our results suggest a potential association between daily diet soft drink consumption and vascular outcomes. However, the mechanisms by which soft drinks may affect vascular events are unclear. There is a need for further research before any conclusions can be drawn regarding the potential health consequences of diet soft drink consumption."

References
1. Gardener H et al (2012). Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan Study. Journal of General Internal Medicine. DOI 10.1007/s11606-011-1968-2
2. The Journal of General Internal Medicine is the official journal of the Society of General Internal Medicine.
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Consuming fish during pregnancy improves offspring’s cognitive development and prosocial conduct

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Can pregnant women improve their progeny’s intelligence by eating fish? A study recently submitted to the American Journal of Clinical Nutrition and coordinated by the University of Granada professor Cristina Campoy Folgoso revealed that infants born to mothers who consumed more fish during pregnancy score higher in verbal intelligence and fine motor skill tests, and present an increased prosocial behavior.

This study was conducted within the framework of the NUTRIMENTHE project (“Effect of diet on offspring’s cognitive development”), which received funding of 5.9 million Euros from the European 7th Framework Programme (7PM). This study was coordinated by the University of Granada professor Cristina Campoy Folgoso.Fish oil is the primary source of long-chain Omega-3 fatty acids as docosahexaenoic acid (DHA), the main component of brain cell membranes. The European Commission has confirmed and supports the healthy effects of DHA as “it contributes to the normal development of the brain and eye of the fetus and breastfed infants”.

Effects of Fish Intake

The NUTRIMENTHE project is focused on the effects that genetic variants and maternal fish intake have on the offspring’s intellectual capacity. The researchers mainly focused on polymorphisms in the fatty acid desaturase (FADS) gene cluster that encodes the delta-5 and delta-6 desaturase enzymes involved in the synthesis of long-chain fatty acids of the series omega-3 and omega-6.

The researchers collected blood samples from 2 000 women at 20 gestational weeks and from the umbilical cord of the infant at birth, and analyzed concentrations of long-chain fatty acids of the series omega-3 and omega-6. Then, they determined the genotype of 18 polymorphisms in the FADS gene cluster. The aim of this study was to assess the effects of maternal fish intake -as a source of Omega-3 and Omega-6 fatty acids- on fetal development, and to determine how the different genotypes affect long-chain fatty acid concentrations in the fetus.

Dr. Pauline Emmett (University of Bristol), Dr. Eva Lattka (Helmholtz Zentrum München, the German Research Center for Environmental Health) and their research teams have determined how FADS gene cluster polymorphisms affect long-chain polyunsaturated fatty acid concentrations in women during pregnancy.

Maternal Genotypes

According to the researchers, fatty acid concentrations in umbilical cord blood depend on maternal and offspring genotypes. Accordingly, maternal genotypes are mainly related with omega-6 fatty acid precursors, and offspring genotypes are related with the more highly elongated fatty acids of the omega-6 series. The study also revealed that concentrations of docosahexaenoic acid (DHA) of the Omega-3 series -main component of brain cell membranes- depend on maternal and offspring genotypes. Dr Lattka states that “the fetal contribution of long-chain polyunsaturated fatty acids of the omega-6 series is more relevant than expected; fetal DHA concentrations depend on maternal and fetal metabolism”, and concludes that “the amount of DHA transmitted to the fetus through the placenta might be crucial for fetal development”.

In a previous study, this research team proved that fish intake during pregnancy is correlated with the IQ in 8-year old children. But, what causes that effect? The study revealed that fish intake is correlated with maternal blood DHA concentrations. However, it has not been clarified whether maternal DHA concentrations are directly correlated with the offspring’s IQ. The NUTRIMENTHE project –which is expected to conclude in 2013- is aimed at elucidating this question.

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Learn the Symptoms of Cervical Cancer

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January is cervical cancer awareness month. This article is the third in a series that discusses cervical cancer, its prevention, symptoms and treatment.

In its early stages, cervical cancer usually has no symptoms. It develops slowly, beginning as a pre-cancerous condition called dysplasia. Symptoms of cervical cancer often do not begin until the cancer spreads into nearby tissue.

Cervical cancer starts in the lower part of the uterus that opens at the top of the vagina. If cervical cancer spreads into nearby tissue, symptoms may include:

  • Increased vaginal discharge including discharge that is pale, watery, pink, brown, bloody or foul-smelling
  • Abnormal vaginal bleeding between periods, after intercourse, or after menopause
  • Periods become heavier and last longer than usual
  • Any bleeding after menopause
  • Pain during intercourse
These symptoms can also be caused by other conditions, so it is best to contact a physician for a diagnosis. If interested in making an appointment with a Penn Medicine physician, call 1-800-789-PENN (7366) or make an online appointment here.
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A glass of milk a day could benefit your brain

Monday, January 30, 2012

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New research finds milk drinkers scored better on memory and brain function tests

Pouring at least one glass of milk each day could not only boost your intake of much-needed key nutrients, but it could also positively impact your brain and mental performance, according to a recent study in the International Dairy Journal.1 Researchers found that adults with higher intakes of milk and milk products scored significantly higher on memory and other brain function tests than those who drank little to no milk. Milk drinkers were five times less likely to "fail" the test, compared to non milk drinkers.

Researchers at the University of Maine put more than 900 men and women ages 23 to 98 through a series of brain tests – including visual-spatial, verbal and working memory tests – and tracked the milk consumption habits of the participants. In the series of eight different measures of mental performance, regardless of age and through all tests, those who drank at least one glass of milk each day had an advantage. The highest scores for all eight outcomes were observed for those with the highest intakes of milk and milk products compared to those with low and infrequent milk intakes. The benefits persisted even after controlling for other factors that can affect brain health, including cardiovascular health and other lifestyle and diet factors. In fact, milk drinkers tended to have healthier diets overall, but there was something about milk intake specifically that offered the brain health advantage, according to the researchers.

In addition to the many established health benefits of milk from bone health to cardiovascular health, the potential to stave off mental decline may represent a novel benefit with great potential to impact the aging population. While more research is needed, the scientists suggest some of milk's nutrients may have a direct effect on brain function and that "easily implemented lifestyle changes that individuals can make present an opportunity to slow or prevent neuropsychological dysfunction."

New and emerging brain health benefits are just one more reason to start each day with lowfat or fat free milk. Whether in a latte, in a smoothie, on your favorite cereal, or straight from the glass, milk at breakfast can be a key part of a healthy breakfast that help sets you up for a successful day. The 2010 Dietary Guidelines for Americans recommend three glasses of lowfat or fat free milk daily for adults and each 8-ounce glass contains nine essential nutrients Americans need, including calcium and vitamin D.

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Alcohol consumption and risk of colon cancer

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A study based on more than 87,000 women and 47,000 men in the Nurses' Health Study and the Health Professionals Follow-up Study, looks at whether there is a link between colon cancer and alcohol, and if so at what level of consumption, and the importance of a family history of the disease. A total of 1,801 cases of colon cancer were diagnosed during follow-up from 1980 onwards.

The authors results found that subjects with a family history, whose average alcohol intake was 30 or more grams per day (about 2 ½ typical drinks by US standards or 4 UK units) had an increase in their risk of colon cancer. Those at greatest risk also ate the most red meat, smoked the most, and had the lowest intake of folate (suggesting they ate fewer green vegetables and cereals. Hence, these people have the most unhealthy lifestyles in general of the populations studied. There was not a significant association between alcohol consumption and colon cancer among subjects without a positive family history in this study.

Forum reviewers were concerned that the pattern of drinking (regularly or binge drinking) was not assessed, and that there was not a consistent increase in risk of cancer with greater alcohol intake found. Further, adequate folate intake was found to lower risk, with the highest risk for subjects with a positive family history of colon cancer, low levels of folate, and in the highest category of alcohol consumption, indicating the importance of other lifestyle facts such as a healthy diet.

The present study provides some support for an association between higher levels of alcohol intake and the risk of colon cancer among subjects with a positive family history of such cancer. It should be noted that there have been changes in the guidelines for screening for colon cancer (by endoscopy, with removal of pre-malignant tumours) and other preventive measures for people with a positive family history of colon cancer, making it hard to draw conclusions on data for colon cancer that is 30 years old. The new recommendation for screening frequency and age at initiation of screening are so different now. At least some of these cases would probably have been prevented if managed according to current guidelines. Such measures could modify the effects of all risk factors for colon cancer in future analyses.
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Alcohol and your heart: Friend or foe?

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A meta-analysis done by the Centre for Addiction and Mental Health (CAMH) into the relationship between alcohol consumption and heart disease provides new insight into the long-held belief that drinking a glass of red wine a day can help protect against heart disease.

"It's complicated," says Dr. Juergen Rehm, director of social and epidemiological research at CAMH. Dr. Rehm's paper, co-authored by Michael Roerecke, was recently published in the journal Addiction. "While a cardioprotective association between alcohol use and ischaemic heart disease exists, it cannot be assumed for all drinkers, even at low levels of intake," says Dr. Rehm.

Ischaemic heart disease is a common cause of illness and death in the Western world. Symptoms are angina, heart pain, and heart failure. Based on 44 studies, the analyses used 38,627 ischaemic heart disease events (including deaths) among 957,684 people.

"We see substantial variation across studies, in particular for an average consumption of one to two drinks a day," says Dr. Rehm. The protective association may vary by gender, drinking patterns, and the specific health effects of interest. Differential risk curves were found by sex, with higher risk for morbidity and mortality in women.

Moreover, for any particular individual, the relationship between alcohol consumption and ischemic heart disease should not be isolated from other disease outcomes. Even at low levels, alcohol intake can have a detrimental effect on many other disease outcomes, including on several cancers.

"Even one drink a day increases risk of breast cancer, for example," says Dr. Rehm. "However, with as little as one drink a day, the net effect on mortality is still beneficial. After this, the net risk increases with every drink."

"If someone binge drinks even once a month, any health benefits from light to moderate drinking disappear." Binge drinking is defined more than four drinks on one occasion for women, and more than five for men.

Given the complex, potentially beneficial or detrimental effects of alcohol on ischaemic heart disease in addition to the detrimental effects on other disease categories, any advice by physicians on individual drinking has to take the individual risk constellation (such as familial predisposition for certain diseases and behavior with respect to other risk factors) into consideration.

"More evidence on the overall benefit-risk ratio of average alcohol consumption in relation to ischaemic heart disease and other diseases is needed in order to inform the general public or physicians about safe or low-risk drinking levels," the study concludes. "Findings from this study support current low-risk drinking guidelines, if these recognize lower drinking limits for women."
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The Future of Breast Cancer Treatment

Kevin Fox MD, is the Mariann T. and Robert J. MacDonald Professor of Medicine and medical director of the Rena Rowan Breast Center at Penn’s Abramson Cancer Center. He treats all aspects of early stage and advanced stage breast cancer researches adjuvant therapy of breast cancer. This post is part three of a three-part series looking at advances in breast cancer prevention, screening, diagnosis and treatment.

The future of breast cancer treatment


The next 20 years will bring more targeted therapy for the treatment of advanced breast cancer, and will most likely see a decline in the use of chemotherapy.

Special drugs will continue to be developed that attack special “targets” that exist only in breast cancer cells. These drugs, we hope, will spare the patient’s normal cells, thus avoiding many of the side effects we have come to expect from chemotherapy.

Drugs with names like PARP inhibitors and MTOR inhibitors will become part of our everyday language, and more drugs that target HER-2 like trastuzumab will be released in the very near future.

Twenty years from now, many things about breast cancer treatment will have changed again. Tomograms may replace mammograms as the standard method of breast cancer detection,surgeons may not need to remove lymph nodes at all, and radiation therapy may become shorter in duration. Perhaps chemotherapy will have become a thing of the past.

Whatever the case, treatments will be better, more patients will be cured, and in every respect, there will be less suffering for patients at every stage of treatment.

Read parts one and two of this series in breast cancer advancements.

Learn more about breast cancer treatment at the Abramson Cancer Center in Philadelphia.

Watch conference presentations from the 2011 Life After Breast Cancer conference.

Penn's Abramson Cancer Center is a national cancer center in Philadelphia providing comprehensive cancer treatment, clinical trials for cancer and is a cancer research center. The National Cancer Institute has designated the Abramson Cancer Center a Comprehensive Cancer Center, one of only 40 such cancer centers in the United States.
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Marijuana Bud

Sunday, January 29, 2012



"Despite the ongoing political debate regarding the legality of medical marijuana, clinical investigations of the therapeutic use of cannabinoids are now more prevalent than at any time in history. 

Around the globe, similarly controlled trials are also taking place. A 2010 review by researchers in Germany reports that since 2005 there have been 37 controlled studies assessing the safety and efficacy of marijuana and its naturally occurring compounds in a total of 2,563 subjects. By contrast, most FDA-approved drugs go through far fewer trials involving far fewer subjects.

While much of the renewed interest in cannabinoid therapeutics is a result of the discovery of the endocannabinoid regulatory system (which we describe in detail later in this booklet), some of this increased attention is also due to the growing body of testimonials from medical cannabis patients and their physicians. Nevertheless, despite this influx of anecdotal reports, much of the modern investigation of medical cannabis remains limited to preclinical (animal) studies of individual cannabinoids (e.g. THC or cannabidiol) and/or synthetic cannabinoid agonists (e.g., dronabinol or WIN 55,212-2) rather than clinical trial investigations involving whole plant material. Because of the US government's strong public policy stance against any use of cannabis, the bulk of this modern cannabinoid research is predictably taking place outside the United States.

As clinical research into the therapeutic value of cannabinoids has proliferated – there are now an estimated 20,000 published papers in the scientific literature analyzing marijuana and its constituents — so too has investigators' understanding of cannabis' remarkable capability to combat disease. Whereas researchers in the 1970s, 80s, and 90s primarily assessed cannabis' ability to temporarily alleviate various disease symptoms — such as the nausea associated with cancer chemotherapy — scientists today are exploring the potential role of cannabinoids to modify disease. 

Of particular interest, scientists are investigating cannabinoids' capacity to moderate autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, as well as their role in the treatment of neurological disorders such as Alzheimer's disease and amyotrophic lateral sclerosis (a.k.a. Lou Gehrig's disease.) In fact, in 2009, the American Medical Association (AMA) resolved for the first time in the organization's history "that marijuana's status as a federal Schedule I controlled substance be reviewed with the goal of facilitating the conduct of clinical research and development of cannabinoid-based medicines."

Investigators are also studying the anti-cancer activities of cannabis, as a growing body of preclinical and clinical data concludes that cannabinoids can reduce the spread of specific cancer cells via apoptosis (programmed cell death) and by the inhibition of angiogenesis (the formation of new blood vessels). Arguably, these latter findings represent far broader and more significant applications for cannabinoid therapeutics than researchers could have imagined some thirty or even twenty years ago."



Medicinal oil made from cannabis buds, when ingested (see dosage instructions below) three to four times daily, for three months, will destroy leukemia and cancer cells.   This means ingesting about 1/5 teaspoon, or one ml, or one gram per day....So that over two months one has ingested 60 grams or 60 ml in total.  One must start with one half a rice-grain size portion of cannabis oil, thrice daily....and, over the next four weeks,  work up to the amount of about four rice-grains of cannabis oil, four times per day, for two months.  One must take one gram or one ml. per day for 60 days.


Please note:  Cannabis oil ingestion is being recommended for the destruction of cancer cells in the body....It is not being recommended for recreational use.  Also please note:  The results of healing come from the ingestion of the oil from the marijuana buds, not from smoking the buds.  The high heat from a burning marijuana cigarette actually destroy the 'medicinal qualities' contained within the cannabis buds.  The process of making the marijuana oil ensures that the heat never exceeds the 212 degrees of boiling water.



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Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed

Friday, January 27, 2012

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Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.

A study published this week in the journal Carcinogenesis shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed.

“It’s a rather dramatic effect,” says Rajesh Agarwal, PhD, investigator at the University of Colorado Cancer Center and professor at the Skaggs School of Pharmaceutical Sciences.

Note: Here's more from Wkipedia:

Human case reports and results from laboratory and animal studies provide preliminary evidence that grape seed extract may affect heart diseases such as high blood pressure and high cholesterol.[1] By limiting lipid oxidation, phenolics in grape seeds may reduce risk of heart disease, such as by inhibiting platelet aggregation and reducing inflammation.[2] While such studies are promising, more research including long-term studies in humans is needed to confirm initial findings.

A polyphenol contained in grape seeds is resveratrol, which may interfere with cancer cell growth and proliferation, as well as induce apoptosis, among other potential chemopreventive effects.[3][4]

Preliminary research shows that grape seed extract may have other possible anti-disease properties, such as in laboratory models of
• wound healing —- grape seed proanthocyanidins induced vascular endothelial growth factor and accelerated healing of injured skin in mice[5]
• tooth decay -- seed phenolics may inhibit oral sugar metabolism and retard growth of certain bacteria that cause dental caries[6]
• osteoporosis -- grape seed extracts enhanced bone density and strength in experimental animals[7]
• skin cancer -- grape seed proanthocyanidins decreased tumor numbers and reduced the malignancy of papillomas[8]
• ultraviolet damage to skin -— dietary proanthocyanidins may protect against carcinogenesis and provide supplementation for sunscreen protection[9]
• anti-viral[10][11]

and from the National Center for Complementary and Alternative Medicine
• Studies have found that some compounds of grape seed extract may be effective in relieving symptoms of chronic venous insufficiency (when veins have problems sending blood from the legs back to the heart) and reducing edema (swelling) after an injury or surgery.
• Small randomized trials have found beneficial effects of grape seed extract for diabetic retinopathy (an eye problem caused by diabetes) and for vascular fragility (weakness in small blood vessels). Larger trials are needed to confirm these findings.
• Grape seed extract contains antioxidants, which help prevent cell damage caused by free radicals (highly reactive molecules that can damage cell function). Preliminary studies have shown some beneficial antioxidant effects; however, more research is needed.
• A study funded by the National Cancer Institute (NCI) found that grape seed extract did not reduce the hardening of breast tissue that can occur after radiation therapy for breast cancer.
• NCI is also funding studies to evaluate whether grape seed extract is effective in preventing breast cancer in postmenopausal women and prostate cancer.
• NCCAM is studying whether the action of grape seed extract and its components may benefit the heart or help prevent cognitive decline, Alzheimer's disease, and other brain disorders. Another study is investigating the effects of grape seed extract on colon cancer.

Specifically, the paper shows that grape seed extract both damages cancer cells’ DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51 and DNA repair foci).

“Yet we saw absolutely no toxicity to the mice, themselves,” Agarwal says.

Again, the grape seed extract killed the cancer cells but not the healthy cells.
“I think the whole point is that cancer cells have a lot of defective pathways and they are very vulnerable if you target those pathways. The same is not true of healthy cells,” Agarwal says.

The Agarwal Lab hopes to move in the direction of clinical trials of grape seed extract, potentially as an addition to second-line therapies that target head and neck squamous cell carcinoma that has failed a first treatment.
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Jon's Health Tips - Latest Health Research

I will certainly stop eating protein before major surgery in the future - but just not into total diet restriction:

Protein-free diet good for you?


Limiting certain essential nutrients for several days before surgery—either protein or amino acids—may reduce the risk of serious surgical complications such as heart attack or stroke, according to a new Harvard School of Public Health (HSPH) study.

The results are significant because they pinpoint protein as an important substance to eliminate from the diet before surgery to avoid complications. Stroke risk related to cardiovascular surgery ranges from 0.8% to 9.7%, depending on the procedure. Heart attack risk is 3% to 4%.

In numerous animal studies over the past few decades, scientists have found that long-term dietary restriction can improve health and lengthen life. Benefits include increased stress resistance, reduced inflammation, improved blood sugar regulation, and better cardiovascular health—and many of these benefits extend to humans.




I really, really don't know what to do about Vitamin D


Vitamin D could help combat the effects of aging in eyes

Vitamin D statement- European Menopause and Andropause Society

Osteoporosis is a common condition in postmenopausal women leading to bone fractures. However, there is now evidence that vitamin D deficiency is also associated with other medical conditions important in older women. These include cardiovascular disease, diabetes, cancer, infections and neurodegenerative disease. Regular sunlight exposure (without sunscreens) for 15 minutes, 3-4 times a week, in the middle of the day in summer can generate healthy levels. Supplements of vitamin D are recommended for those women who cannot obtain the required quantity through sun exposure and diet. The recommended daily allowance is 600 IU/day increasing to 800IU/day for those aged 71 years and older.

Low vitamin D levels linked to depression,

But:

When It Comes to Heart Health, How Much Is Too Much Vitamin D?

New research by Johns Hopkins scientists suggests that vitamin D, long known to be important for bone health and in recent years also for heart protection, may stop conferring cardiovascular benefits and could actually cause harm as levels in the blood rise above the low end of what is considered normal.

Study leader Muhammad Amer, M.D., an assistant professor in the division of general internal medicine at the Johns Hopkins University School of Medicine, says his findings show that increasing levels of vitamin D in the blood are linked with lower levels of a popular marker for cardiovascular inflammation — c-reactive protein (also known as CRP).

Amer and his colleague Rehan Qayyum, M.D., M.H.S., examined data from more than 15,000 adult participants in the continuous National Health and Nutrition Examination Survey, a nationally representative sample, from 2001 and 2006. They found an inverse relationship between vitamin D and CRP in adults without cardiovascular symptoms but with relatively low vitamin D levels. Healthier, lower levels of inflammation were found in people with normal or close to normal vitamin D levels. But beyond blood levels of 21 nanograms per milliliter of 25-Hydroxyvitamin D — considered the low end of the normal range for vitamin D — any additional increase in vitamin D was associated with an increase in CRP, a factor linked to stiffening of the blood vessels and an increased risk of cardiovascular problems.

“The inflammation that was curtailed by vitamin D does not appear to be curtailed at higher levels of vitamin D,” says Amer, whose newest finding appears in the Jan. 15 issue of the American Journal of Cardiology. “Clearly vitamin D is important for your heart health, especially if you have low blood levels of vitamin D. It reduces cardiovascular inflammation and atherosclerosis, and may reduce mortality, but it appears that at some point it can be too much of a good thing.”

Amer says consumers should exercise caution before taking supplements and physicians should know the potential risks. Each 100 international unit of vitamin D ingested daily produces about a one nanogram per milliliter increase 25-Hydroxyvitamin D levels in the blood. “People taking vitamin D supplements need to be sure the supplements are necessary,” Amer says. “Those pills could have unforeseen consequences to health even if they are not technically toxic.”

Amer and Qayyum, also an assistant professor in the division of general internal medicine at Hopkins, say the biological and molecular mechanisms that account for the loss of cardiovascular benefits are unclear.

Vitamin D is often called the “sunshine vitamin” because its primary source is the sun. It is found in very few foods, though commercially sold milk is usually fortified with it. As people spend more and more time indoors and slather their bodies with sunscreen, concern is rising that many are vitamin D-deficient, Amer notes.

As a result, Amer says, many doctors prescribe vitamin D supplements, and many consumers, after reading news stories about the vitamin’s benefits, dose themselves. Older women often take large doses to fight and prevent osteoporosis.




Well this is good news: (McDonalds fish sandwich is fried in a combination of sunflower and canola oil. Read more:) Wendy's fired items, on the other hand are cooked in soy, corn, cottonseed, and hydrogenated soy oil. Read more


No cardiac risk with food fried in olive, sunflower oil



In a Mediterranean country where olive and sunflower oils are the most commonly used fats for frying, and where large amounts of fried foods are consumed both at and away from home, no association was observed between fried food consumption and the risk of coronary heart disease or death.


I've been good about eating a bit of dark chocolate every day (2 squares):

Cocoa could prevent intestinal pathologies such as colon cancer



The growing interest amongst the scientific community to identify those foods capable of preventing diseases has now categorized cocoa as a 'superfood'. It has been recognised as an excellent source of phytochemical compounds, which offer potential health benefits.

Headed by scientists from the Institute of Food Science and Technology and Nutrition (ICTAN) and recently published in the Molecular Nutrition & Food Research journal, the new study supports this idea and upholds that cacao consumption helps to prevent intestinal complaints linked to oxidative stress, such as the onset of chemically induced colon carcinogenesis.

Although more research is required to determine what bioactive compounds in cocoa are responsible for such effects, the authors conclude that a cocoa-rich diet seems capable of reducing induced oxidative stress. It could also have protection properties in the initial stages of colon cancer as it reduces premalignant neoplastic lesion formation.

I've been pretty good on fruits and vegetables, including olive oil and a limited amount of orange juice every day:

Plant Flavonoid Luteolin Blocks Cell Signaling Pathways in Colon Cancer Cells



Luteolin is a flavonoid commonly found in fruit and vegetables. Dietary sources include celery, green pepper, thyme, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, navel oranges, and oregano. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain. New research published in BioMed Central's open access journal BMC Gastroenterology shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells. Colon cancer is the second most frequent cause of cancer-related death in the Western World.

I do get a lot of fiber in my diet - that's good, right?


Increase Dietary Fiber, Decrease Disease



We should all be eating more dietary fiber to improve our health -- that's the message from a health review by scientists in India. The team has looked at research conducted into dietary fiber during the last few decades across the globe and now suggests that to avoid initial problems, such as intestinal gas and loose stool, it is best to increase intake gradually and to spread high-fiber foods out throughout the day, at meals and snacks. Writing in the International Journal of Food Safety, Nutrition and Public Health, the team offers fruit, vegetables, whole-grain foods, such as muesli and porridge, beans and pulses, as readily available foods rich in dietary fiber.

Dietary fiber, also known as roughage, is the general term of the non-digestible parts of the fruit and vegetable products we eat. There are two forms soluble and insoluble. Soluble (prebiotic, viscous) fiber that is readily broken down or fermented in the colon into physiologically active byproducts and gases. The second form is insoluble fiber, which is metabolically inert, but absorbs water as it passes through the digestive system, providing bulk for the intestinal muscles to work against and easing defecation.

Given that dietary fiber has physiological actions such as reducing cholesterol and attenuating blood glucose, maintaining gastrointestinal health, and positively affecting calcium bioavailability and immune function, it is important for the current generation and future generations that this component of our diets be reasserted through education and information.

"Consuming adequate quantities of DF can lead to improvements in gastrointestinal health, and reduction in susceptibility to diseases such as diverticular disease, heart disease, colon cancer, and diabetes. Increased consumption has also been associated with increased satiety and weight loss," the team concludes. Given the ready availability particularly in the West and in the relatively richer parts of the developing world of vegetables, fruit and other foods high in dietary fiber it is a matter of recommending that people eat more dietary fiber rather than consistently taking the unhealthy low-fiber option throughout their lives.

But:

Diets high in fiber MAY CAUSE, not protect against, diverticulosis




For more than 40 years, scientists and physicians have thought eating a high-fiber diet lowered a person's risk of diverticulosis, a disease of the large intestine in which pouches develop in the colon wall. A new study of more than 2,000 people reveals the opposite may be true.

"We were surprised to find that a low-fiber diet was not associated with a higher prevalence of asymptomatic diverticulosis," said Peery. In fact, the study found those with the lowest fiber intake were 30 percent less likely to develop diverticula than those with the highest fiber intake.

Diverticulosis affects about one-third of adults over age 60 in the United States. Although most cases are asymptomatic, when complications develop they can be severe, resulting in infections, bleeding, intestinal perforations and even death. Health care associated with such complications costs an estimated $2.5 billion per year.

Since the late 1960s, doctors have recommended a high-fiber diet to regulate bowel movements and reduce the risk of diverticulosis. This recommendation is based on the idea that a low fiber diet will cause constipation and in turn generate diverticula as a result of increased pressure in the colon. However, few studies have been conducted to back up that assumption. "Our findings dispute commonly-held beliefs because asymptomatic diverticulosis has never been rigorously studied," said Peery.

The study also found constipation was not a risk factor and that having more frequent bowel movements actually increased a person's risk. Compared to those with fewer than seven bowel movements per week, individuals with more than 15 bowel movements per week were 70 percent more likely to develop diverticulosis.

The study found no association between diverticulosis and physical inactivity, intake of fat, or intake of red meat. The disease's causes remain unknown, but the researchers believe gut flora may play a role.

I don't think I'm ready for virtual reality exercise yet, but if I did it I'd be more likely to be open to it:


Virtual reality-enhanced exercise = +cognitive benefit for older adults

Enhancing cognition in older adults also changes personality



A program designed to boost cognition in older adults also increased their openness to new experiences, researchers report, demonstrating for the first time that a non-drug intervention in older adults can change a personality trait once thought to be fixed throughout the lifespan.



Other things I do, or eat that are good:

Grapes may help prevent age-related blindness


Alcohol & polyphenols in red wine both fight cardiovascular disease

Moderate red wine drinking may help cut women's breast cancer risk


Benefits of statin therapy may extend beyond lowering lipids

Chlorophyll in green vegetables can prevent cancer

Omega-3 fatty acids could prevent and treat nerve damage

I still eat too much of these:

Red & processed meat consumption = increased pancreatic cancer risk.


This is interesting:


Dispelling the low-fat-is-healthy myth




Dozens of studies, many from Harvard School of Public Health (HSPH) researchers, have shown that low-fat diets are no better for health than moderate- or high-fat diets—and for many people, may be worse. A regular blueberry muffin from a national coffee shop chain has 450 calories on average and most of those calories come from carbohydrates, primarily white flour and sugar. However, now that national chains have eliminated trans fats, a regular muffin does have heart-healthy fat, usually from soybean or canola oil. A low-fat muffin has about the same amount of calories, but contains more carbohydrates and sugar—and about 60% more sodium (700 milligrams)—than a regular muffin.



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Cervical Cancer Risk and Prevention

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January is cervical cancer awareness month. This article is part two in a series that discusses cervical cancer, its prevention, symptoms and treatment.

Cervical Cancer Risk and Prevention

Most risk factors for cervical cancer, like age and family history, cannot be prevented. Patients who feel they are at higher risk for cervical cancer may benefit from consulting with a risk assessment specialist through one of Penn Medicine’s programs at the Abramson Cancer Center or the Joan Karnell Cancer Center at Pennsylvania Hospital.

Cervical Cancer Risk Factors

Risk factors affect the chance of developing cervical cancer. Having a risk factor, or even several, does not mean that someone will get cancer.
All women need to be aware of the risk factors for cervical cancer, and what they can do to prevent it.

Penn Medicine gynecologists work with patients to identify their risk of developing cervical cancer and the steps they can take to lower their risk.
The human papilloma virus, or HPV, causes the majority of cervical cancers. HPV is a group of more than 100 related viruses that can infect cells on the surface of the skin, genitals, anus, mouth and throat.

Genital HPV is the most common sexually transmitted virus in the United States. An estimated 75 to 80 percent of males and females will be infected with HPV during their lifetime. For most people, the virus clears on its own. When it doesn’t, HPV can cause genital warts, precancerous dysplasia and cervical, vulvar or vaginal

Other risk factors for cervical cancer include:
  • Having sex early
  • Multiple sexual partners, or having sex with someone who has had multiple partners
  • Sexual partners who have multiple partners or who participate in high-risk sexual activities
  • A weakened immune system
  • Lack of regular pap tests
  • Weakened immune system
  • Smoking
  • Long term birth control use
  • Having more than 5 children
  • DES exposure
  • Poor economic status or inadequate health coverage
  • HPV infection or genital warts
Cervical cancer is easily treated if it is caught early, so it is important for women to get regular screening exams including a Pap test and HPV test.

Cervical Cancer Prevention


Penn Medicine gynecologists recommend several methods to prevent cervical cancer. Regular screenings, vaccines for preventing the human papilloma virus (HPV) and lifestyle choices can prevent cervical cancer or help find cervical cancer at an early stage when it is most treatable.

Pelvic Exam, Pap Test and HPV Test

Pelvic exams, Pap test screening and HPV testing can detect cervical cancer in its early stages. Pap tests are one of the most effective screening tools used to determine if women have infections, abnormal (unhealthy) cervical cells, cervical cancer or other reproductive problems. A Pap test is the screening of cells scraped from the cervix during a pelvic exam that are examined under a microscope. Pap tests screen for pre-cancers and cancer, but do not provide a final diagnosis.

The American College of Obstetrics and Gynecologists (ACOG) recommends that cervical cancer screening begin at age 21. Most women under the age 30 should undergo cervical screening once every two years and women 30 and older with no other risk factors can be screened every three years. These are not the guidelines. See below.

  • Under 21 and never sexually active: No pap
  • Adolescent: Within 3 yrs of onset of sexual activity
  • 21 to 29 years old: Annual pelvic exam with Pap Smear
  • 30 to 64 years old: ACOG recommends annual Pap. After 3 consecutive normal paps, screening = every 2-3 years. (This is only if the patient has never had CIN 2 or 3, is not immune-compromised or HIV-positive, and has not been exposed to diethylstilbestrol (DES) in utero.
  • 65 and older:  Pap Smears may be disontinued if the woman has had 3 or more consecutive negative paps; no abnormal tests in the previous 10 years; no history of cervical cancer; no DES-exposure; is HIV negative and has a normal immune system; and has no other risk factors for STDs. 
The above was taken from http://www.kltv.com/story/10543955/acog-changes-pap-smear-guidelines. i had trouble accessing the ACOG site.

Preventing HPV: The HPV vaccine

Vaccines are now available that protect against four major types of HPV, including the two types that cause about 70 percent of cervical cancer cases and two types that cause about 90 percent of genital warts.

The HPV vaccine is expected to be long-lasting, but because the vaccine does not protect against all HPV types that cause cervical cancer vaccinated women still need cervical cancer screening (Pap tests and HPV tests). The vaccine does prevent HPV, but does not protect against HPV exposure before vaccination. Also add that it is not a cure.

Condoms do not protect completely against HPV because they don't cover all of the potential HPV-infected areas of the body. However, condoms do provide some protection against HPV, and they protect against HIV and other sexually transmitted diseases.

Although penetrative intercourse is not necessary to get and spread HPV women can do the following to decrease their risk of cervical cancer:
  • Stay up-to-date with recommended paps and exams.
  • Avoid smoking
  • Avoid early onset of sexual activity and sexual activity with people who have had several sexual partners.
  • Use condoms
  • Try to maintain a healthy immune system
  • Limit the amount of sexual partners

Women may avoid HPV, and therefore reduce their risk of cervical cancer, by waiting to have sex until they are older and limiting the number of sexual partners. They should also avoid having sex with anyone who has had multiple sexual partners.

Learn more about cervical cancer treatment at the Abramson Cancer Center.

Learn more about the Jordan Center for Gynecologic Cancer.

Learn more about the MacDonald Women’s Cancer Risk Evaluation Center.
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LEARNING DISABILITIES | MANAGE IT WITH HOMEOPATHY

Thursday, January 26, 2012 · Posted in ,


      Learning disabilities, or learning disorders, are an umbrella term for a wide variety of learning problems. A learning disability is not a problem with intelligence or motivation. Kids with learning disabilities aren’t lazy or dumb. In fact, most are just as smart as everyone else. Their brains are simply wired differently. This difference affects how they receive and process information.
     
   LD is not a disease entity. It is believed to be a processing deficit in the Central nervous system. It is not a single disorder but a term that refers to a group of disorders.
It is believed to be a neurological disorder that affects the brain's ability to receive, process, store and respond to information [disorder of the CNS, which effects mental processing]. The
main indicator of LD is a significant difference between the expected ability of an individual and his performance. The term learning disability is used to describe the seeming unexplained difficulty a person of at least average intelligence has in acquiring basic academic skills
The important thing to remember is that most kids with learning disabilities are just as smart as everyone else. They just need to be taught in ways that are tailored to their unique learning styles. By learning more about learning disabilities in general, and your child’s learning difficulties in particular, you can help pave the way for success at school and beyond.

Types of Learning disability

       Some types of learning disabilities are categorized by the cognitive processing problem. This means your child may have issues with one of the following:
    Attention – The ability to stay on task in a sustained, selective, or divided way.
    Working Memory – The ability to retain and process information for short time periods.
    Processing Speed – The rate at which the brain handles information.
    Long-Term Memory – The ability to both store and recall information for later use.
    Visual Processing – The ability to perceive, analyze, and think in visual images.
    Auditory Processing – The ability to perceive and conceptualize what is heard.
    Logic and Reasoning – The ability to reason, prioritize, and plan.


What causes Learning Disability?

       It is almost universally accepted that learning disorders are the result of varying types of malfunctions in the way the brain operates. Unfortunately, there is very little information on what actually causes these malfunctions.

        Smoking or excessive alcohol consumption or drug use by a mother during pregnancy, may be at least partially responsible for certain learning and behavioral disorders. After birth, exposure to second-hand smoke can also affect a child's brain development as can an infection involving the central nervous system, physical trauma or poor nutrition.
There has been a lot of media attention given to rumors that an ingredient used in childhood vaccinations, thimerosal, may be a contributing factor in the case of autism. While scientific studies have not completely ruled this out, the evidence so far is heavily weighted against it being true. It should also be noted that thimerosal was removed from vaccination formulations in 2001 and the rate of autism spectrum disorders being diagnosed has not changed markedly.
Learning and behavioral disorders seem to run in families so it seems they may have a genetic component, meaning they seem to be inherited.

Problems during pregnancy and birth - LD may be caused by illness or injury during or before birth. It may also be caused by drug and alcohol use during pregnancy, low birth weight, lack of oxygen and premature or prolonged labor.
Incidents after birth - Head injuries, nutritional deprivation and exposure to toxic substances (i.e. lead) can contribute to LD.  Learning disabilities are NOT caused by economic disadvantage, environmental factors or cultural differences. In fact, there is frequently no apparent cause for LD.

Signs and symptoms of Learning Disability

         Learning disabilities look very different from one child to another. One child may struggle with reading and spelling, while another loves books but can’t understand math. Still another child may have difficulty understanding what others are saying or communicating out loud. The problems are very different, but they are all learning disorders.
The following checklist lists some common red flags for learning disorders.

A.     Preschool signs and symptoms of learning disabilities

    Problems pronouncing words
    Trouble finding the right word
    Difficulty rhyming
    Trouble learning the alphabet, numbers, colors, shapes, days of the week
    Difficulty following directions or learning routines
    Difficulty controlling crayons, pencils, and scissors or coloring within the lines
    Trouble with buttons, zippers, snaps, learning to tie shoes

B.     Grades K-4 signs and symptoms of learning disabilities
    Trouble learning the connection between letters and sounds
    Unable to blend sounds to make words
    Confuses basic words when reading
    Consistently misspells words and makes frequent reading errors
    Trouble learning basic math concepts
    Difficulty telling time and remembering sequences
    Slow to learn new skills

C.     Grades 5-8 signs and symptoms of learning disabilities
    Difficulty with reading comprehension or math skills
    Trouble with open-ended test questions and word problems
    Dislikes reading and writing; avoids reading aloud
    Spells the same word differently in a single document
    Poor organizational skills (bedroom, homework, desk is messy and disorganized)
    Trouble following classroom discussions and expressing thoughts aloud
    Poor handwriting

How to deal with a learning disabled child?

         All children need love, encouragement, and support, and for kids with learning disabilities, such positive reinforcement can help ensure that they emerge with a strong sense of self-worth, confidence, and the determination to keep going even when things are tough. Your job as a parent is not to “cure” the learning disability, but to give your child the social and emotional tools he or she needs to work through challenges.

Talk to your child about learning disabilities

Children with learning disabilities must be assured that they are not dumb or lazy. They are intelligent people who have trouble learning because their minds process words or information differently. It is not easy to talk with your child about a disability that you do not fully understand. Be informed. It is important to be honest and optimistic-explain to your child that they struggle with learning, but that they can learn. Focus on your child's talents and strengths. Tell them you are confident that with effort and the right help they will be able to meet the challenge and succeed!

Focus on strengths, not just weaknesses:-
Your child is not defined by his or her learning disability. A learning disability represents one area of weakness, but there are many more areas of strengths. Focus on your child’s gifts and talents. Your child’s life—and schedule—shouldn’t revolve around the learning disability. Nurture the activities where he or she excels, and make plenty of time for them.

Identify how your child learns best
Is your child a visual learner, an auditory learner, or a kinesthetic learner? Once you’ve figured out how he or she learns best, you can take steps to make sure that type of learning is reinforced in the classroom and during home study.

Tips for visual learners:
  • Use books, videos, computers, visual aids, and flashcards.
  • Make detailed, color-coded or highlighted notes.
  • Make outlines, diagrams, and lists.
  • Use drawings and illustrations (preferably in color).
  • Take detailed notes in class.
Tips for auditory learners:
  • Read notes or study materials out loud.
  • Use word associations and verbal repetition to memorize.
  • Study with other students. Talk things through.
  • Listen to books on tape or other audio recordings.
  • Use a tape recorder to listen to lectures again later.
Tips for kinesthetic learners:
  • Get hands on. Do experiments and take field trips.
  • Use activity-based study tools, like role-playing or model building.
  • Study in small groups and take frequent breaks.
  • Use memory games and flash cards.
  • Study with music on in the background.
    
 Work on the relationship between letters and words. Teach younger children how to spell a few special words, such as their own names, the names of pets or favorite cartoon characters, or words they see frequently like stop or exit.
 Help your child understand that language is made up of sounds, syllables, and words. Sing songs and read rhyming books. Play word games; for instance, think of words that rhyme with dog or begin with p.
    Teach letter sounds. Sound out letters and words. Make up your own silly words with your child.
    Sound out new words and encourage your child to spell by speaking each sound aloud. Notice spelling patterns. Point out similarities between words, such as fall, ball, and hall or cat, fat, and hat.

Tips for helping with schoolwork

  • Show an interest in your child's homework. Inquire about the subjects and the work to be done. Ask questions that require answers longer than one or two words.
  • Help your child organize homework materials before beginning.
  • Establish a regular time with your child to do homework-developing a schedule helps avoid procrastination.
  • Find a specific place for your child to do homework that has lots of light, quiet, and plenty of work space.
  • Encourage your child to ask questions and search for answers, taking the time to figure out correct answers.
  • Make sure your child backs up answers with facts and evidence.
  • Practice school-taught skills at home.
  • Relate homework to your child's everyday life. For instance, teach fractions and measurements as you prepare a favorite food together.
  • Be a role model-take the opportunity to read a book or newspaper or write a letter while your child studies.
  • Praise your child for both the small steps and big leaps in the right direction.
Work as a team to help your child

         If the evaluation shows that your child has a learning disability, your child is eligible for special education services. If eligible, you will work with a team of professionals, including your child's teacher, to develop an Individualized Education Program (IEP). The IEP is a written document summarizing your child's current educational performance; annual goals and short-term objectives; nature and projected duration of your child's special services; and methods for evaluating progress. For students 16 years and older, an IEP must include a transition plan to move the student from school to the "real world."
If your child does not qualify for special education, it is still important for you to work with your child's teacher to develop an informal program that meets your child's learning needs. You are a vital part of your child's education!

 Manage Learning Disability with Homeopathy

A homeopath is one who is artistically trained to deal with a case related to mental and emotional plains. In case of learning disability a complete and detailed history should be figured out from the pregnancy period to the day (mental and physical health of the mother during delivery, type of delivery, cry after delivery, weight of the baby, milestone development, understanding, will, reactions to emotions….Etc).
            After case taking and assessments of learning disability the homeopath will explain the way of treatment and medication( constitutional medicine). The remedies will differ from person to person as it is figured out by individualization.
 I am going to give you some commonly prescribed medicine which should be taken by your homeopath’s advice.

·        Belladonna
·        Baryta carb
·        Calcarea carb
·        carcinosen
·        Silicea
·        Natrum muraticum
·        Phosphorus
·        Lycopodium
·        Hyosymus
·        Tuberculinum
·        Medorrhinum
·        Sulphur
·        Arsenic alb etc


References: www.helpguide.org
                  www.ldonline.org
                   www.learningdisabilitiesinfo.com

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