On the basis of skin involvement of the scope of systemic scleroderma will be divided into the following four types. (1) the rapid onset of systemic scleroderma, a symmetry of hand, foot and facial skin tight changed, hardening and thickening, and involving the proximal limbs and neck, spread to the trunk, with lung, heart, gastrointestinal tract Or offal such as kidney damage. Anti-nuclear antibody positive, a small number of patients anti-centromere-positive. Characterized by skin lesions progress quickly, damage to internal organs appeared earlier, the poor prognosis, 10-year survival rate is 40% -60%. (2) limitations of systemic scleroderma skin lesions confined to the finger, forearm and leg remote and face and neck, for symmetry change bear skin, hardening and thickening, with Raynaud's phenomenon, can the latter part of a pulmonary hypertension And the cut-off that kind change. Most of the patients anti-centromere-positive, some patients showed CREST syndrome. This type relatively good prognosis, 10-year survival rate is greater than 70 percent. (3) overlap syndrome diffuse or systemic scleroderma limitations of the merger of one or more other connective tissue diseases. (4) No skin-curing systemic scleroderma less than 1 percent of the systemic scleroderma patients only offal hardening of the skin damage without change. For the performance; ① esophageal activities barriers, expansion of the duodenum and colon kit form; ② Raynaud's phenomenon, a wrinkle-telangiectasia, obstacles and esophageal activities oliguric renal failure; ③ more symptoms associated with pulmonary hypertension or pulmonary disease.
