Suffering from chronic gout tophi and more chronic arthritis patients, the crystallization of uric acid in the body will be deposited in the cartilage and synovial membrane, and soft tissue, the formation of tophi, and blood in the higher concentration of uric acid, with The longer period of disease, may be deposited, the more tophi, and sometimes will affect the blood vessels and kidneys, causing serious renal failure, nephrotic more serious and difficult to create a vicious cycle of uric acid excretion, the Tophi Also the more deposition. Often the site of deposition tophi many, including the ears, hands, elbows, Achilles tendon, ankle or toe, and sometimes even give rise to local ulcer and difficult healing, and even the latest addition to requiring surgery. Patients and cause serious deformation or chronic joint symptoms of severe deformation of the foot when the patient may cause serious problems on the shoes. In addition, the risk of kidney stones occur with increased serum uric acid concentrations increase, and often lead to renal disease, renal failure may be subject to after hemodialysis, which is caused gout patients died one of the main causes of death.
