Four dangerous complications of gout

Thursday, July 3, 2008 · Posted in

Patients suffering from gout, in sugar and fat metabolism will be significantly decreased, making it easy with all kinds of serious diseases: [Diabetes] Diabetes and gout because both are in metabolic disorders caused by disease, it is easy with the patients. Diabetes is the regulation of blood sugar because of a lack of insulin hormone, resulting in a continuous state of high blood sugar, and uric acid and blood glucose levels between the very relevant, usually high uric acid, blood glucose levels will be higher. [Hypertension / high blood lipids: Most patients with gout is more body fat, excessive accumulation of body fat tends to cause arteriosclerosis and hypertension, and patients with gout because of bias on the daily intake of dietary fat, high-calorie food, so in the neutral fat content is very high , Cholesterol values are generally have more than the normal standard, hyperlipidemia is a good one of the ethnic groups. [Myocardial infarction / heart disease - a narrow Gout patients prone to cardiovascular arteriosclerosis of the situation, resulting in the blood can not be fully served on the heart, blood circulation dysfunctional, cause heart disease or myocardial infarction narrow the probability of particularly high, especially on the original with hyperlipidemia Gout patients are more prone to heart disease. [Cerebral vascular obstacles: The same is guided by the problem in atherosclerosis, the difference in the brain occur. Its symptoms include headache, dizziness, numbness or tingling hands and feet, serious, the patients have lost their sense of danger and even death, the patient volume, in addition to angiography, the brain needs to be done CT, MRI examination.
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Tophi arthritis and chronic gout

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Suffering from chronic gout tophi and more chronic arthritis patients, the crystallization of uric acid in the body will be deposited in the cartilage and synovial membrane, and soft tissue, the formation of tophi, and blood in the higher concentration of uric acid, with The longer period of disease, may be deposited, the more tophi, and sometimes will affect the blood vessels and kidneys, causing serious renal failure, nephrotic more serious and difficult to create a vicious cycle of uric acid excretion, the Tophi Also the more deposition. Often the site of deposition tophi many, including the ears, hands, elbows, Achilles tendon, ankle or toe, and sometimes even give rise to local ulcer and difficult healing, and even the latest addition to requiring surgery. Patients and cause serious deformation or chronic joint symptoms of severe deformation of the foot when the patient may cause serious problems on the shoes. In addition, the risk of kidney stones occur with increased serum uric acid concentrations increase, and often lead to renal disease, renal failure may be subject to after hemodialysis, which is caused gout patients died one of the main causes of death.
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Secondary hyperuricemia, or gout

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Secondary hyperuricemia, or gout that is a minor clinical manifestations, secondary to any genetic or acquired pathological process. Clinical mainly divided into two categories: A. generate excessive uric acid 1) excessive amount of high-purine food intake, 2) bone marrow proliferative diseases: multiple myeloma, 3) lymphoproliferative disease: infectious mononucleosis Cell Histiocytosis, 4) hemolytic anemia, 5) tumors, 6) psoriasis, 7) the cumulative lying liver disease: found I, III, V, VI, 8) fructose intake, 9) is not hereditary fructose Tolerance, 10) hypoxemia and organizations hypoperfusion, 11) intense muscle movement, 12) acute and chronic alcohol poisoning, B. reduce uric acid excretion 1) renal insufficiency, 2) ketoacidosis, 3) lactic acid Acidosis, 4) tubular absorb increased uric acid salts, 5) dehydrating agent and diuretic, 6) hyperparathyroidism, 7) parathyroid mechanism may be, 8) hypothyroidism, 9) hypertension, 10) Drugs: ethambutol, pyrazinamide, nicotinic acid, acetyl acid water Yang, 11) lead poisoning. 12) patients with cancer chemotherapy and radiotherapy, 13) adrenal mechanism may be, 14) renal diabetes insipidus, 15) hunger.
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Hyperuricemia and gout What's the difference between

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Hyperuricemia is uric acid in the blood more than a normal state. Many reasons can cause blood uric acid salt content increased, and gout is one of the most common causes. Gout is in the long-term hyperuricemia circumstances, result in human organs and tissues in diseases. The main result of gouty arthritis, gout and kidney disease, gout and kidney stones, gout and heart disease, hypertension and gout, and other serious complications. Hyperuricemia can also say is a prelude to gout, but not necessarily able to evolve into gout disease, the patients have gout and hyperuricemia.
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Gouty arthritis and gout What is the relationship between

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Gout is a metabolic disorder and beautiful reduce the excretion of uric acid caused by a group of diseases. The clinical performance are: asymptomatic hyperuricemia, gout arthritis stone, urinary stone and renal disease. Gouty arthritis is when uric acid salts in the articular cartilage or synovial deposition, leading to synovial tissue and the inflammatory response. Hyperuricemia is the most important biochemical basis of gout, but is not synonymous with gout. As improvement of living standards, changes in the structure of diet, and many affected uric acid excretion of drugs (diuretics) the extensive use of hyperuricemia is in fact the incidence of the adult male is 5% -7%, the researchers statistics About 5% -12% of hyperuricemia in patients with gout for the eventual development. When the blood uric acid level of more than 420 micro-Mount / l, arthritis and gout in uric acid kidney stones, or the risk of a significant increase
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Tophi can take stone surgery

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According to statistics, gout patients in about 20% to 30% of body surface of a stone, the stone occurred in the vicinity of the joints and limbs, and joint function in patients with serious decline, maimed, or even loss of self-care ability. Some patients stone not long after surgery wound healing, some doctors do not want to do this surgery. Gout can then stone surgery stones » How surgery » Tophi formation of tophi is because long-term patients increased serum uric acid, uric acid formation of sodium (MSU), deposited in various tissues and organs formed stones. In addition to internal organs outside the brain can be a stone to see most of the kidney stone. Surface stones mainly occurred in the vicinity of the joints and limbs, the stone sooner or later, the growth rate and increased blood levels of uric acid, hyperuricemia duration, and acute arthritis in the same number of joint attack was positively correlated. Stone serious bone and joint, hand or foot bones of several pieces of stone were all occupied. If the initial stones in the soft tissue, the skin can thinning, Pokui, MSU crystallization of the outflow or small stones to form ulcers and sinus, repeated bacterial infections, break a few years or 10 years can not be healed, the merger also osteomyelitis Are not uncommon. So as soon as possible surgery stones. ① preoperative preparation before the surgery should be the first of serum uric acid to normal or near normal levels, after a result of uric acid avoid excessive impact on healing. ② need to physically do the surgery X-ray imaging, X-ray easily through the stone, but the soft tissue in the stone often can be seen surrounding the density slightly higher than the whole of the massive image. X-ray through the little bone, stone density was significantly lower than bone density, X-ray film common wormhole-like, Chuanzao kind, the kind of low-density cellular bone defects, serious one or several pieces of bone and parts All missing. Gout is a metabolic syndrome ③ a disease, should be actively treating hypertension, diabetes and renal dysfunction and other merger-related diseases, to be in stable condition after surgery. Surgical operation is primarily aimed at joints and near the stone: ① where stone diameter of more than 2 cm or more than a stone so that the pool in uric acid increased significantly, the impact of descending uric acid treatment. ② have ulcers, sinus or osteomyelitis formed to break long-term, non-union. ③ stones affect joint function, significantly restricted the activities of patients. If surgery is not invaded stone and bone joints, regardless of whether the merger ulcer and sinus, the majority can and will be coated with stone removed, the incision in five to ten days to heal. Such as stone and bone and joint deep, large piece of stone removed, should no longer use keys, and other equipment will be scraping the remnants of stone fragments as far as possible eliminate, or stone debris will continue in the overflow from the wound, healing effects, drainage should be done at this time Treatment, more than in January after the drainage is not sealed, should be done in the second removal. A small number of serious bone damage, the need to buy bones, joints integration, and the truncated limb, so to promote tophi surgery sooner the better. ① down after dealing with uric acid, a small stone after stone in the blood return to the residue dissolved so that the blood uric acid increased rapidly, if not promptly and effectively to drop acid treatment, after the majority of people in the non-operative joint acute arthritis Some multi-joint alternating repeated incidence. At this point in addition to eat food rich in purine, down uric acid to increase the amount of drugs, and for seven days after the previous day to a daily service 1 ~ 3 mg colchicine, can significantly reduce acute arthritis. ② strengthen hypertension, coronary heart disease, diabetes, kidney disease and other diseases related to the treatment of these diseases under control.
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Tophi can take stone surgery

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According to statistics, gout patients in about 20% to 30% of body surface of a stone, the stone occurred in the vicinity of the joints and limbs, and joint function in patients with serious decline, maimed, or even loss of self-care ability. Some patients stone not long after surgery wound healing, some doctors do not want to do this surgery. Gout can then stone surgery stones » How surgery » Tophi formation of tophi is because long-term patients increased serum uric acid, uric acid formation of sodium (MSU), deposited in various tissues and organs formed stones. In addition to internal organs outside the brain can be a stone to see most of the kidney stone. Surface stones mainly occurred in the vicinity of the joints and limbs, the stone sooner or later, the growth rate and increased blood levels of uric acid, hyperuricemia duration, and acute arthritis in the same number of joint attack was positively correlated. Stone serious bone and joint, hand or foot bones of several pieces of stone were all occupied. If the initial stones in the soft tissue, the skin can thinning, Pokui, MSU crystallization of the outflow or small stones to form ulcers and sinus, repeated bacterial infections, break a few years or 10 years can not be healed, the merger also osteomyelitis Are not uncommon. So as soon as possible surgery stones. ① preoperative preparation before the surgery should be the first of serum uric acid to normal or near normal levels, after a result of uric acid avoid excessive impact on healing. ② need to physically do the surgery X-ray imaging, X-ray easily through the stone, but the soft tissue in the stone often can be seen surrounding the density slightly higher than the whole of the massive image. X-ray through the little bone, stone density was significantly lower than bone density, X-ray film common wormhole-like, Chuanzao kind, the kind of low-density cellular bone defects, serious one or several pieces of bone and parts All missing. Gout is a metabolic syndrome ③ a disease, should be actively treating hypertension, diabetes and renal dysfunction and other merger-related diseases, to be in stable condition after surgery. Surgical operation is primarily aimed at joints and near the stone: ① where stone diameter of more than 2 cm or more than a stone so that the pool in uric acid increased significantly, the impact of descending uric acid treatment. ② have ulcers, sinus or osteomyelitis formed to break long-term, non-union. ③ stones affect joint function, significantly restricted the activities of patients. If surgery is not invaded stone and bone joints, regardless of whether the merger ulcer and sinus, the majority can and will be coated with stone removed, the incision in five to ten days to heal. Such as stone and bone and joint deep, large piece of stone removed, should no longer use keys, and other equipment will be scraping the remnants of stone fragments as far as possible eliminate, or stone debris will continue in the overflow from the wound, healing effects, drainage should be done at this time Treatment, more than in January after the drainage is not sealed, should be done in the second removal. A small number of serious bone damage, the need to buy bones, joints integration, and the truncated limb, so to promote tophi surgery sooner the better. ① down after dealing with uric acid, a small stone after stone in the blood return to the residue dissolved so that the blood uric acid increased rapidly, if not promptly and effectively to drop acid treatment, after the majority of people in the non-operative joint acute arthritis Some multi-joint alternating repeated incidence. At this point in addition to eat food rich in purine, down uric acid to increase the amount of drugs, and for seven days after the previous day to a daily service 1 ~ 3 mg colchicine, can significantly reduce acute arthritis. ② strengthen hypertension, coronary heart disease, diabetes, kidney disease and other diseases related to the treatment of these diseases under control.
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