On the basis of skin involvement of the scope of systemic scleroderma will be divided into the following four types. (1) the rapid onset of systemic scleroderma, a symmetry of hand, foot and facial skin tight changed, hardening and thickening, and involving the proximal limbs and neck, spread to the trunk, with lung, heart, gastrointestinal tract Or offal such as kidney damage. Anti-nuclear antibody positive, a small number of...