(1) smoking some high incidence area residents esophageal cancer, Smoking rate is very high, and some local residents do not smoke, very rare esophageal cancer. This is because cigarettes contain several nitrosamines, a carcinogenic nitrosamines have a strong role. (2) drinking Western Europe and North America the survey found that many patients with the history of a large number of drinking wine or mostly workers and the staff concerned. Patients with esophageal cancer in the United States drink whiskey than the general population 25 times greater,higher 10 times. Alcohol itself has no carcinogenic effects, it may be carcinogenic solvents, carcinogens easy access to esophageal mucosa, but also enable alcohol dehydration esophageal mucosa caused esophageal mucosa damage, the incidence of esophageal cancer is to create conditions. (3) bad eating habits and long-term consumption of malnutrition overheating, tough, rough and hot food irritation food, may cause esophageal mucosal injury, repeated damage can cause mucosal hyperplasia of change, the final lead to cancer. Tumor Institute of the Chinese Academy of Sciences in the human body, the environment, the role of carcinogenic nitrosamines found in the study, esophageal cancer Linxian high incidence area residents consumption sauerkraut contains a variety of nitrosamines, and to prove that the consumption of the sauerkraut with esophageal cancer the incidence rate is proportional. In addition, Shantou University Medical College report, the high incidence area of Guangdong Province esophageal cancer Nan'ao County living water, fish sauce, shrimp paste, pickles, radish dry in a variety of nitrosamines contained, and these foods often in the course of pickled fungal contamination , mold can promote food nitrosamine content significantly higher. But the mold of esophageal cancer animal model has been confirmed in Streptomyces role in the pathogenesis of esophageal cancer. Esophageal cancer is generally high incidence area in the soil is poor, poor nutrition in poor areas, lack of vitamin diet, especially vitamin C and vitamin B2, the lack of protein and essential amino acids. Can the esophageal mucosa hyperplasia, change as further cause cancer. Trace elements iron, molybdenum, zinc, etc., and also the lack of related to the occurrence of esophageal cancer. (4) the esophageal mucosa chronic inflammation of the esophagus stimulated some state and abnormal esophageal diseases such as diverticulitis, scar Clip narrow, esophageal inflammation, etc. Achalasia, Meku malignant transformation can occur formed esophageal cancer. (5) genetic susceptibility scientists After extensive investigation and found that esophageal cancer has been significantly family aggregation phenomenon.
