Many patients with liver cancer with liver cirrhosis, Cirrhosis in decompensated liver function, often occur suddenly or gradually oliguric or no urine, azotemia, and other functional renal failure in the performance, and at this time there is no organic kidney disease, such as liver and kidney integrated said levy (hepatic or renal failure, the majority of patients with HRS people have such a deepening of jaundice, hepatosplenomegaly, hypoproteinemia and refractory ascites liver failure, such as the performance of the disease is characterized by the end of deep coma, oliguric serious sexual and blood pressure drop.
Hepatic function at the onset of renal failure in patients with renal no organic disease, but renal blood flow and glomerular filtration rate is likely to reduce serious is the continued contraction of renal vascular results. A study, liver dysfunction induced renal vasoconstriction is the result of renal failure liver a crucial link to the following factors may cause renal vasoconstriction causes.
(1) Tension increased renal sympathetic nerve Liver function severely damaged in the circumstances, the following factors could increase tension renal sympathetic: ① hypovolemia; ② visceral hemodynamic changes;
(B) a renin angiotensin system activities increase Liver dysfunction in patients with hepatocellular carcinoma, normally have a clear renin angiotensin increased, leading to renal vasoconstriction.
(C) kallikrein a bradykinin abnormal system activity in patients with severe cirrhosis kallikrein relaxed bradykinin reduced, and plasma renin activity and angiotensin increase. These changes result in a comprehensive vasodilator and vasoconstrictor activity lowering agent activity increased, leading to renal vasoconstriction.
(D) lack of prostaglandin
(5) Endotoxemia
(6) False neurotransmitter accumulation In short, liver failure that occurred when the renal vasoconstriction factors can be summarized into two categories: one category is serious liver function The obstacles, or damage to the liver can not be removed from the cycle of toxic substances, such as endotoxin and false neurotransmitter, and so other is a low blood volume and portal hypertension caused by reduced effective circulating blood volume.
Clinical manifestations: hepatorenal syndrome in patients with hypoproteinemia addition, portal hypertension, the ascites in liver function and jaundice, and other under-wide The clinical manifestations, but also with renal failure clinical performance to a renal failure depends on the incidence of clinical priorities, the acute onset, may suddenly appeared oliguria, anuria, azotemia, illness in a short period of time the deterioration. Once patients with hepatocellular carcinoma hepatorenal syndrome, and its poor prognosis.
Hepatic function at the onset of renal failure in patients with renal no organic disease, but renal blood flow and glomerular filtration rate is likely to reduce serious is the continued contraction of renal vascular results. A study, liver dysfunction induced renal vasoconstriction is the result of renal failure liver a crucial link to the following factors may cause renal vasoconstriction causes.
(1) Tension increased renal sympathetic nerve Liver function severely damaged in the circumstances, the following factors could increase tension renal sympathetic: ① hypovolemia; ② visceral hemodynamic changes;
(B) a renin angiotensin system activities increase Liver dysfunction in patients with hepatocellular carcinoma, normally have a clear renin angiotensin increased, leading to renal vasoconstriction.
(C) kallikrein a bradykinin abnormal system activity in patients with severe cirrhosis kallikrein relaxed bradykinin reduced, and plasma renin activity and angiotensin increase. These changes result in a comprehensive vasodilator and vasoconstrictor activity lowering agent activity increased, leading to renal vasoconstriction.
(D) lack of prostaglandin
(5) Endotoxemia
(6) False neurotransmitter accumulation In short, liver failure that occurred when the renal vasoconstriction factors can be summarized into two categories: one category is serious liver function The obstacles, or damage to the liver can not be removed from the cycle of toxic substances, such as endotoxin and false neurotransmitter, and so other is a low blood volume and portal hypertension caused by reduced effective circulating blood volume.
Clinical manifestations: hepatorenal syndrome in patients with hypoproteinemia addition, portal hypertension, the ascites in liver function and jaundice, and other under-wide The clinical manifestations, but also with renal failure clinical performance to a renal failure depends on the incidence of clinical priorities, the acute onset, may suddenly appeared oliguria, anuria, azotemia, illness in a short period of time the deterioration. Once patients with hepatocellular carcinoma hepatorenal syndrome, and its poor prognosis.
