(1) for patients with liver diseases, consideration should be given to the possibility of drug-induced, it should be asked in detail about the history of medication, such as dosage, administration and the beginning of time to stop, such as the interval from the onset. Literature data show that about 50% to 70% of patients with drug-induced hepatitis after treatment in two weeks, the incidence of about 80% -90% in the eight weeks of incidence. In addition, should also be aware of the occupational contact with drugs or chemicals.
(2) whether the attention of fever, skin and mucous damage, skin rashes, joint pain and eosinophilia, and other allergic symptoms. We must pay attention to the size of the liver, because some drugs can cause asymptomatic hepatomegaly.
(3) It should be noted with acute and chronic viral hepatitis, obstructive jaundice and cirrhosis of identification, such as.
(4) liver biopsy examination, we can see that portal District inflammation, and a large number of eosinophil infiltration and cholestasis, it is conducive to drug-induced hepatitis diagnosis.
(5) Some people think that after the resumption of the liver, skin allergies do drugs test in the diagnosis of help. Some people recommend using a small dose of the drug provocation test, were measured before and after the administration of a variety of serum enzyme activity, many times in a row after the administration of significantly higher than before treatment could be considered drug-induced hepatitis. Drug provocation test but only 40% to 60% positive, and some duplication of administration a long time, provocation test there is still a risk, it can not be used lightly.
(2) whether the attention of fever, skin and mucous damage, skin rashes, joint pain and eosinophilia, and other allergic symptoms. We must pay attention to the size of the liver, because some drugs can cause asymptomatic hepatomegaly.
(3) It should be noted with acute and chronic viral hepatitis, obstructive jaundice and cirrhosis of identification, such as.
(4) liver biopsy examination, we can see that portal District inflammation, and a large number of eosinophil infiltration and cholestasis, it is conducive to drug-induced hepatitis diagnosis.
(5) Some people think that after the resumption of the liver, skin allergies do drugs test in the diagnosis of help. Some people recommend using a small dose of the drug provocation test, were measured before and after the administration of a variety of serum enzyme activity, many times in a row after the administration of significantly higher than before treatment could be considered drug-induced hepatitis. Drug provocation test but only 40% to 60% positive, and some duplication of administration a long time, provocation test there is still a risk, it can not be used lightly.
