Prognostic factors affecting breast cancer

Monday, March 31, 2008 · Posted in

Solid impact on the prognosis of breast cancer in many, their mutual relations complicated, it should be integrated various factors to estimate the prognosis of patients.
The main factors affecting the prognosis in the following areas:
(1)-Clinical storm;
(2) Age: Case is generally believed that the younger the rapid development of tumors, lymph node metastasis, and poor prognosis;
(3) the primary tumor size and local infiltration: in the absence of regional lymph node metastases and distant metastasis circumstances, the primary local infiltration and the greater the more serious, the worse the prognosis;
(4) lymph node metastasis;
(5) the pathological tumor type and degree of differentiation;
(6) steroid hormone receptor;
(7) rate of cell proliferation and DNA content;
(8) oncogene.
The etiology of breast cancer has not solved the problem, it really can be used for a very limited means of prevention, but cautiously to reduce breast cancer risk of several measures it is possible, if appropriate restraint adolescent fat and animal protein intake to increase sports activities to encourage breast-feeding babies, menopausal women to avoid using estrogen after menopause appropriate increasing physical activity, controlling total calorie and fat intake, and avoid unnecessary radiation exposure, etc..
Surgical treatment of breast cancer has a long history, there are various changes in the scope of operations. In recent years, the development of breast cancer because of a new concept, that the incidence of breast cancer is one from systemic disease, breast at the same time in order to keep the shape and upper limb function in a wide range of less than surgical resection of the whole milk and Comprehensive Application of radiotherapy and chemotherapy. In Europe and the United States and other countries, radical or modified radical mastectomy of the application has been reduced for local surgery and radiotherapy for patients with breast cancer cases has reached 20% to 30%, taking into account for breast reconstruction. At present in the diagnosis and treatment of breast cancer, has not only satisfied with the malignancy and whether the lymph node metastasis, but called for postoperative treatment and prognosis provide reference data, such as the observation of blood vessels, lymphatic invasion, receptor determination Flow Detection of DNA content of cells and cell cycle phase in the distribution of monoclonal antibodies for diagnosis and treatment. In recent years, with the cancer gene research has been constantly deepened, and many found the prognosis of breast cancer-related genes. Expected in the near future, people can pass the test to determine the prognosis of patients as well as on the high risk of relapse cases select the appropriate adjuvant therapy to improve the cure rate.

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