Renal failure is common clinical symptoms, sub-acute and chronic. Acute renal failure (ARF) could reasonably accurate diagnosis of treatment, often to cure or alleviate. Acute and chronic renal failure (CRF) the distinction, first, clinical diagnosis, based mainly on the length of history, information and other indicators and the other is diagnosis, renal pathology is the identification of the ARF and the CRF gold standard, but with the current national emergency renal biopsy Conditions of the hospital was not universal. Therefore, the choice of the ARF and the identification and assessment of the CRF non-invasive indicator is extremely important. We have treated Section I of the 100 cases of kidney failure patients (of which 82 cases of the renal pathology) of the clinical data analysis, results showed that: (1) disease duration is to distinguish between acute and chronic renal failure basis. CRF50 half the total of cases in the period of less than one year, of which one-third more radical onset, the disease with less than three months. Therefore, the duration of disease as a basis for judgement CRF is not particularly reliable. Literature and information Division I, the diagnosis of renal biopsy after a higher proportion of changes. (2) current domestic popularity has used "B" super-size measuring kidney. Is generally believed that the kidney volume increase seen at ARF, kidney volume narrow view of chronic renal failure. Our data suggest that both acute renal failure or slow, the real increase or reduce the kidney is only one-third each, the majority of cases of kidney normal size, the people of this part of B-measurement of the size of the kidney acute and chronic renal failure identification no help . Recently, we found that "B" super-renal measured in real terms than the thickness measurement of renal size more meaningful. (3) of nail creatinine is a non-invasive, simple screening method, the value of serum creatinine level of response three months ago. The onset or misprision of history is unknown, patients with normal kidney size, nail creatinine determination to learn three months ago renal function, its specificity of 84 percent, more than two information can be used as the cover. (4) anemia is one of the CRF clinical manifestations, has been printed in textbooks, as the ARF and the identification of one of CRF. In addition, hemolytic uremic syndrome can be caused by a severe ARF anemia, ARF acute when the expansion could lead to mild to moderate anemia. Acute interstitial nephritis acute nephritis due to a decline in promoting Red can also be expressed as anemia. Therefore, we believe that to anemia as a distinction between the ARF and the CRF indicators are not reliable. (5) increase in nocturnal enuresis, Niaobi Chong declined CRF is the clinical manifestations. I ARF cases by half in less than 1.015 Niaobi Chong, renal biopsy of the small organization is obvious between the disease, this phenomenon could explain the ARF Niaobi Chong declined. (6) urine cytology and other physical components of the examination in clinical diagnosis can not be ignored. The total number of urine in the tubular cells, necrosis cells, the type and number of categories, often prompted tubular necrosis, the more the number of its more serious illness, kidney function worse; acute interstitial nephritis, acute renal failure in the urine There eosinophil urine in the large number of red blood cells, red blood cells in particular hints of acute renal failure caused glomerulonephritis. (7) ARF particularly acute tubular necrosis, of urine, brush border antigen, urine ATP-binding protein levels to rise in the differential diagnosis. (8) the information we have failed to prompt serum calcium, phosphorus concentration on the ARF and the identification of the CRF to help.